Define the chromatographic bed
The packed bed is the core of DAC column performance.
Stationary-phase chemistry and particle size
Column diameter and target bed height
Packing slurry and solvent
Operating and packing pressure
Laboratory Instrument Guide
How to Choose a DAC Dynamic Axial Compression Column
Select a DAC column by method scale-up, column diameter, bed height, packing material, pressure, flow, sample load, and system compatibility.
Direct Answer
Selection summary
Select a DAC column only after defining the stationary phase, target bed, sample load, flow and pressure, solvent compatibility, packing procedure, and connected preparative system. Column diameter alone does not determine achievable purity or productivity.
Decision framework
Match the complete system
The column must match the pump, detector, tubing, and collector.
System flow and pressure capability
Connection sizes and wetted materials
Detector flow cell and fraction timing
Pressure monitoring and safety
Use scale-up data
Confirm loading and productivity experimentally.
Analytical or pilot separation
Loading study and purity target
Cycle time and solvent consumption
Cleaning and repacking plan
Information to prepare before requesting a quotation
Stationary phase
Column diameter and bed height
Sample load
Flow and pressure
Solvent compatibility
Packing method
Connected system configuration
Related instruments
These products are relevant starting points; final suitability depends on the complete method and configuration.
DAC Series
DAC Dynamic Axial Compression Column
Dynamic axial compression chromatography columns for preparative purification and process development.
Workflow fit
Method scale-up -> Column packing or selection -> Purification run -> Fraction collection
RFQ: Column size and pressure scope
RFQ: Pump, detector, collector, and DAC column configuration
Preparative chromatography columns / Purification scale-up
Details
WOOK 8500
WOOK 8500 Dynamic Axial Preparative Chromatography System
Preparative chromatography platform built around dynamic axial compression column technology for purification and scale-up work.
Workflow fit
Method scale-up -> Column packing or selection -> Purification run -> Fraction collection
RFQ: Column size and pressure scope
RFQ: Pump, detector, collector, and DAC column configuration
Natural product purification / Pharmaceutical intermediate separation
Details
LC500P
LC500P Dynamic Axial Preparative Chromatography System
Preparative LC system for purification tasks requiring DAC column compatibility and flexible module selection.
Workflow fit
Method scale-up -> Column packing or selection -> Purification run -> Fraction collection
RFQ: Column size and pressure scope
RFQ: Pump, detector, collector, and DAC column configuration
Preparative HPLC purification / Compound isolation
Details