Start from separation evidence
Preparative scale-up should begin with an analytical or pilot method.
Target compound and impurities
Required purity and recovery
Stationary and mobile phase
Retention, selectivity, and loading study
Laboratory Instrument Guide
How to Choose a Preparative Chromatography System
Plan preparative LC scale-up by target purity, sample load, flow, pressure, column, pump, detector, fraction collection, and solvent handling.
Direct Answer
Selection summary
Choose a preparative chromatography system from successful separation data. Define target purity and recovery, sample load, solvent system, column, flow and pressure, pump materials, detector and flow cell, fraction collection, software, solvent use, and scale-up evidence.
Decision framework
Size the configured system
Pump, detector, column, tubing, and collector must operate as one flow path.
Required flow and pressure
Column diameter and bed length
Detector flow cell and signal range
Fraction-collection logic and vessel capacity
Calculate operational scope
Productivity depends on more than the instrument purchase.
Solvent consumption and recovery
Sample preparation and injection
Cleaning and column packing
Installation, training, and spare parts
Information to prepare before requesting a quotation
Analytical chromatogram
Sample load and concentration
Purity and recovery target
Solvent system
Flow, pressure, and column
Detector and collector
Daily production target
Related instruments
These products are relevant starting points; final suitability depends on the complete method and configuration.
WOOK 8500
WOOK 8500 Dynamic Axial Preparative Chromatography System
Preparative chromatography platform built around dynamic axial compression column technology for purification and scale-up work.
Workflow fit
Method scale-up -> Column packing or selection -> Purification run -> Fraction collection
RFQ: Column size and pressure scope
RFQ: Pump, detector, collector, and DAC column configuration
Natural product purification / Pharmaceutical intermediate separation
Details
LC500P
LC500P Dynamic Axial Preparative Chromatography System
Preparative LC system for purification tasks requiring DAC column compatibility and flexible module selection.
Workflow fit
Method scale-up -> Column packing or selection -> Purification run -> Fraction collection
RFQ: Column size and pressure scope
RFQ: Pump, detector, collector, and DAC column configuration
Preparative HPLC purification / Compound isolation
Details
DAC Series
DAC Dynamic Axial Compression Column
Dynamic axial compression chromatography columns for preparative purification and process development.
Workflow fit
Method scale-up -> Column packing or selection -> Purification run -> Fraction collection
RFQ: Column size and pressure scope
RFQ: Pump, detector, collector, and DAC column configuration
Preparative chromatography columns / Purification scale-up
Details